For example, biologists will mail their specimens to the lab where the microscope resides, maybe on the far side of the globe, but examine the specimen by controlling the microscope from the workstations in their offices. He Internet of the future will connect not only computers, but also large data warehouses and advanced scientific instruments, such as high-powered electron microscopes. Ian Foster, Senior Scientist, Mathematics and Computer Science Division, Argonne National Laboratory Head, Distributed Systems Laboratory, ANL Associate Professor, Department of Computer Science, University of Chicago PROJECT LEADERS Carl Kesselman, Research Associate Professor, Computer Science Department, University of Southern California Project Leader at USC Information Sciences Institute Visiting Associate, Computer Science Department, Caltech Globus: Around the World and onto Your Desktop Statistics, Machine Learning & Predictive Analytics.This study adds further support to the application of DBS in a tic-related network, though factors such as patient sample size and clinical heterogeneity remain as limitations and replication is required.ĭeep brain stimulation Globus pallidus internus Modelling Simulation Tourette syndrome. A subsequent regression analysis correlated these patient-specific simulations to percentage changes in outcome measures in order to identify any significant voxels related to clinical improvement.Ī region within the ventral limbic GPi, specifically on the medial medullary lamina in the pallidum at the level of the AC-PC, was significantly associated with improved tics but not mood or OCB outcome. Electric field simulations were created for each patient using information on electrode location and individual stimulation parameters.
Validated clinical assessments were used to measure tics, OCB, quality of life, anxiety, and depression before DBS and at the latest follow-up (17-82 months). This study of 15 patients with long-term amGPi DBS for severe TS investigated whether a specific anatomical site within the amGPi correlated with optimal clinical outcome for the measures of tics, obsessive compulsive behaviour (OCB), and mood. The thalamus and anteromedial globus pallidus internus (amGPi) have been the most commonly stimulated sites within the cortico-striato thalamic circuit, but an optimal target is yet to be elucidated. Deep brain stimulation (DBS) in patients with severe, refractory Tourette syndrome (TS) has demonstrated promising but variable results thus far.
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